Dr. Ben Payne (Idris Elba) and Ashley Knox (Kate Winslet) are both on their way to Baltimore. Payne must perform an emergency operation and Knox is about to get married. But when bad weather hits, their flight is cancelled. The two of them decide to hire a charter flight together, but bad luck strikes again and their plane crashes somewhere in the mountains. The two strangers must now rely on each other to survive these extreme conditions.