Despite lockdown restrictions, country music legend and longtime marijuana legalisation advocate Willie Nelson will be celebrating 4/20 with a live-streamed variety show.

Celebrating the annual weed-smoking holiday with guests Kacey Musgraves, Angel Olsen, Billy Ray Cyrus, Matthew McConaughey, Jeff Bridges, Margo Price, Ziggy Marley, Tommy Chong and Beto O'Rourke, among other artists, chefs, comedians and educators, the 'Come And Toke It' livestream will launch at 4.20pm CDT (10.20pm Irish time) tonight, April 20.

In keeping with the theme, the variety show promises to present "4 hours and 20 minutes of cannabis-centric entertainment hosted by Willie Nelson himself – all from the comfort of quarantine."

See a full list of the 'Come And Toke It' line-up below:

1 more day until we’re live with @willienelson & @williesreserve this 4/20. #ComeandTokeIt is gonna be one helluva party w/ appearances by @McConaughey @thejeffbridges @thatkevinsmith @ElleKingMusic @billmaher @drivebytruckers @StP_BrokenBones @BillyJoe_Shaver and so many more. pic.twitter.com/De4WRAihkI

— Luck Reunion (@LuckReunion) April 19, 2020

Donations from the stream will go to the Last Prisoner Project, a non-profit organisation dedicated to freeing inmates convicted of nonviolent marijuana crimes. Watch the livestream at 10.20pm Irish time here.

Until then, you can celebrate the day with 'The Hot Press 4/20 Playlist':