The pregnant singer was due to top the bill at the annual festival in the California desert on 15 and 22 April.
Organisers have said Beyonce will headline the event in 2018 instead.
"Following advice of doctors to keep a less rigorous schedule, Beyonce has made the decision to forgo performing at the 2017 Coachella Valley Music & Arts Festival," a statement said.
"However, Goldenvoice and Parkwood are pleased to confirm that she will be a headliner at the 2018 festival. Thank you for your understanding."

The festival organisers have not yet announced who would replace the singer.

Radiohead and Kendrick Lamar will still headline the festival, which takes place over two weeks.

We would like to share our love and happiness. We have been blessed two times over. We are incredibly grateful that our family will be growing by two, and we thank you for your well wishes. - The Carters

A post shared by Beyoncé (@beyonce) on Feb 1, 2017 at 10:39am PST

Beyonce performed at the Grammys earlier this month, where she showed off her baby bump, took home two awards and got a commendation from Adele, who dedicated her Album of the Year award to the singer.