Tonight will see the Foo Fighters front man taking the stage to fill in for the host.
The 48 year old musician is no stranger to the screen, having appeared in The Muppets movie in 2011.
Grohl also infamously had a drum battle with Animal, the Muppet's drummer on the Jimmy Kimmel show a few years later.
Guests tonight will include Kristen Bell, star of recent Netflix hit The Good Place
Alice Cooper will perform on the night, adding to the Halloween theme.
Fans have shared their hopes online that Grohl takes to the drums for Cooper's performance.

Dave is hosting @JimmyKimmelLive on TUE 10/31??‘? Guests @IMKristenBell @RealAliceCooper. Music: ALICE COOPER ?
Watch 11:35/10:35c on @abc

— Foo Fighters (@foofighters) October 30, 2017