Bono and co are set to receive the Ambassador of Conscience Award, which is annually given to those who show exceptional leadership in the fight to protect and promote human rights.
Secretary General Irena Khan said: "From Live Aid in 1985 and Amnesty International's 1986 Conspiracy of Hope tour, through to Live 8, U2 has arguably done more than any other band to highlight the cause of global human rights in general and Amnesty International's work in particular."
"They have inspired and empowered millions with their music and by speaking out on behalf of the poor, the powerless and the oppressed."
The band will be presented with the award in the New Year.